RT Book, Section
A1 Strickler, Samantha
A1 Oropello, John M.
A2 Oropello, John M.
A2 Pastores, Stephen M.
A2 Kvetan, Vladimir
SR Print(0)
ID 1136419122
T1 Critical Care Medicine in the Era of Omics
T2 Critical Care
YR 1
FD 1
PB McGraw-Hill Education
PP New York, NY
SN 9780071820813
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1136419122
RD 2024/04/24
AB KEY  POINTSResearchers  and  physicians  are  now  examining  human  health  and  disease  in  the  context  of  the  human  genome,  epigenome,  transcriptome,  proteome,  and  microbiome.In  critical  illness,  disease  processes  are  multifaceted,  involving  numerous  interactions  between  genes  and  gene  products  rather  than  a  single  locus.Network  medicine  focuses  on  integrating  various  omic  disciplines  to  create  networks  that  explain  healthy  and  diseased  states.Network  model  analysis  of  ARDS  has  revealed  redundancy  in  protein  connectivity,  with  several  proteins  involved  in  multiple  pathways.More  basic  research  needs  to  be  completed,  followed  by  integration  of  genomic,  epigenomic,  transcriptomic,  proteomic,  microbiomic,  and  other  omic  data  to  create  more  network  models  of  critical  illness.