RT Book, Section
A1 McCulloh, Russell J.
A1 Opal, Steven M.
A2 Oropello, John M.
A2 Pastores, Stephen M.
A2 Kvetan, Vladimir
SR Print(0)
ID 1136415642
T1 Sepsis, Septic Shock, and Multiple Organ Failure
T2 Critical Care
YR 1
FD 1
PB McGraw-Hill Education
PP New York, NY
SN 9780071820813
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1136415642
RD 2024/04/25
AB KEY  POINTSSepsis  is  increasing  in  incidence  worldwide.  This  is  the  result  of  a  number  of  factors  including:  the  aging  of  the  population  with  a  large  increase  in  patients  more  than  65  years;  progressive  increase  in  antibiotic  resistance;  increased  reliance  on  implanted  devices,  organ  transplantation  and  other  invasive  surgical  procedures;  and  increasing  prevalence  of  patients  with  long-term  immunosuppressive  diseases  and  medications  who  are  at  risk  for  severe  infection  and  sepsis.Sepsis  is  a  syndrome  consisting  of  a  constellation  of  signs,  symptoms,  hemodynamic,  and  laboratory  findings  caused  by  an  excessive  and/or  dysfunctional  host  immune  response  to  severe  infection.  There  is  currently  no  single  diagnostic  test  sufficient  to  make  a  definitive  diagnosis  of  sepsis.The  key  to  optimal  care  of  the  septic  patient  is  early  recognition  and  early  initiation  of  appropriate  treatment.  This  places  the  responsibility  for  early  recognition  on  the  health  care  team  in  managing  acutely  ill  patients.  The  lack  of  a  rapid  diagnostic  test  and  the  often  subtle  initial  presentation  of  sepsis  make  the  early  detection  of  sepsis  a  real  challenge.Septic  shock  is  a  medical  emergency  and  should  be  treated  as  such.  The  major  therapeutic  approach  is  aggressive  fluid  resuscitation,  early  and  appropriate  antibiotic  therapy,  early  determination  of  the  source  of  the  causative  infection  site  and  source  control  if  possible  (drain  abscess,  remove  necrotic  tissue  or  infected  catheters  or  other  devices,  etc).The  prevention  and  expert  management  of  organ  dysfunction  as  a  result  of  sepsis  is  critical  for  survival  and  prevention  of  long-term  disability.  Expert  supportive  care  by  critical  care  specialists  will  improve  outcomes.