RT Book, Section A1 Patel, Pritul A1 Hosseinian, Leila A2 Oropello, John M. A2 Pastores, Stephen M. A2 Kvetan, Vladimir SR Print(0) ID 1136414640 T1 Acute Kidney Injury and Failure T2 Critical Care YR 1 FD 1 PB McGraw-Hill Education PP New York, NY SN 9780071820813 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1136414640 RD 2024/03/29 AB KEY POINTSCurrent concepts of AKI in sepsis indicate that systemic inflammation, microvascular dysregulation, and mitochondrial alteration, leading to cell death may be more important than global renal hypoperfusion.Urine output and SCr are at best surrogate markers of renal function, but can be “normal” in the presence of renal dysfunction.Recent studies have identified new biomarkers of renal injury that can diagnose AKI earlier than SCr, but these are still in the primary stages of clinical adoption.Prevention of contrast-induced AKI focuses on the use of noniodinated contrast media, minimizing contrast-media volume, avoiding repeat exposure to contrast media, and expanding plasma volume before administration of contrast media.The published literature suggests that periprocedural dialysis has no protective effect against CI-AKI.