RT Book, Section A1 Noto, Christopher A1 Wallace, Mark S. A2 Bajwa, Zahid H. A2 Wootton, R. Joshua A2 Warfield, Carol A. SR Print(0) ID 1131937036 T1 Cannabinoids in Pain Management T2 Principles and Practice of Pain Medicine, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071766838 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1131937036 RD 2024/03/28 AB Cannabis has been utilized as a medicine and in various cultural practices for millennia with accounts of its use dating back over 5000 years.1 There is reference to the use of cannabis for the treatment of headache from the sixth and seventh centuries.2 In the mid-1800s, reports of the therapeutic potential of cannabis entered the medical literature and its use became more widespread.3 However, in the early twentieth century, cannabis was increasingly scrutinized for its psychoactive effects and recreational use, and it was removed from the US Pharmacopoeia in 1942.4 Nonetheless, preclinical studies continued and many neurobehavioral tests confirmed its analgesic effects.5-8 In addition to its use for analgesia, cannabis is under investigation for use in a number of neurological disorders, glaucoma, and as an antiemetic and appetite stimulant.