RT Book, Section A1 Chen, Lucy A1 Mao, Jianren A2 Bajwa, Zahid H. A2 Wootton, R. Joshua A2 Warfield, Carol A. SR Print(0) ID 1131936888 T1 Opioid-Induced Hyperalgesia T2 Principles and Practice of Pain Medicine, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071766838 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1131936888 RD 2024/03/28 AB Opioid analgesics are among the most powerful pain medications used to treat a variety of pain conditions. Activation of opioid receptors produces analgesia, euphoria, respiratory depression, decreased gastrointestinal motility, and cardiovascular effects. Exposure to opioids also can lead to opioid tolerance and opioid-induced hyperalgesia (OIH). The concept of OIH refers to a pronociceptive state induced by exposure to opioids with a paradoxical increase in nociceptive sensitization through changes at the cellular and system level. This chapter will review evidence of OIH from preclinical and clinical studies and discuss the issues relevant to clinical diagnosis and management of OIH.