RT Book, Section A1 LeBel, Alyssa A. A1 Greco, Christine D. A1 Berde, Charles B. A2 Bajwa, Zahid H. A2 Wootton, R. Joshua A2 Warfield, Carol A. SR Print(0) ID 1131936365 T1 Cancer Pain and Palliative Care in Children T2 Principles and Practice of Pain Medicine, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071766838 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1131936365 RD 2024/03/29 AB The prognosis of cancer in children has improved dramatically over the past 40 years. Unlike many adult cancers, pediatric malignancies are often responsive to initial aggressive chemotherapy, radiation, and surgery. Currently, the estimated survival rate for a child (age 0-19) with cancer is 80%. However, these therapies often produce acute and chronic pain problems, such as mucositis, graft versus host disease (GVHD), peripheral and central neuropathic pain, phantom limb pain, prolonged postdural puncture headache, radiation dermatitis, and visceral hyperalgesia. Although treatment-related pain generally exceeds tumor-associated pain in pediatric cancer patients, tumor-associated pain is prevalent and may involve bone, viscera, nerves, and other tissues. In the most common diagnostic category of pediatric cancer, leukemia, presenting in children 2 to 6 years of age, bone pain is secondary to rapid growth of precursor cells in the bone marrow. In adolescents, malignant bone tumors and lymphomas produce most tumor-related pain. The most common solid tumor diagnosed during childhood, central nervous system (CNS) tumor, may induce headache caused by increased intracranial pressure (ICP).