RT Book, Section
A1 Parikh, Amar
A1 Simopoulos, Thomas T.
A2 Bajwa, Zahid H.
A2 Wootton, R. Joshua
A2 Warfield, Carol A.
SR Print(0)
ID 1131934717
T1 Preemptive Analgesia
T2 Principles and Practice of Pain Medicine, 3e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071766838
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1131934717
RD 2024/04/20
AB The  understanding  of  postoperative  pain  has  evolved  greatly  during  the  past  half  century.  Many  laboratory  investigations  have  established  that  peripheral  tissue  injury  during  surgery  can  trigger  a  prolonged  state  of  spinal  cord  excitation.  A  reduction  in  neuronal  thresholds  in  the  central  nervous  system  (CNS)  is  thought  to  amplify  pain  in  postsurgical  patients.  Preemptive  analgesia  is  an  antinociceptive  treatment  targeted  to  block  CNS  hyperexcitability  and  leads  to  a  reduced  postoperative  pain  state.  This  treatment  also  has  the  long-term  goals  of  facilitating  rapid  return  to  usual  baseline  function  as  well  as  decreasing  the  risk  of  chronic  pain.  However,  despite  numerous  investigations,  the  clinical  relevance  of  such  treatment  remains  in  controversy.