RT Book, Section
A1 Lee, Angela
A2 Freeman, Brian S.
A2 Berger, Jeffrey S.
SR Print(0)
ID 1135743809
T1 Antibiotics
T2 Anesthesiology Core Review: Part Two Advanced Exam
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259641770
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1135743809
RD 2024/04/17
AB Surgical  site  infections  (SSIs)  occur  within  30  days  of  surgery  or  within  90  days  if  a  prosthetic  implant.  Antibiotic  prophylaxis  reduces  microorganisms  at  the  operative  site  during  surgery.  Cefazolin  is  the  drug  of  choice  for  many  surgeries  because  it  is  effective  against  streptococcus,  methicillin  susceptible  staphylococci,  and  some  gram-negative  bacteria.  Second-generation  cephalosporins  have  broader  coverage  against  gram-negative  organisms  than  cefazolin.  Cefoxitin  and  cefotetan  also  cover  some  anaerobes.  The  role  of  vancomycin  in  SSI  prophylaxis  is  in  the  methicillin-resistant  staphylococci  colonized  patient.  Antimicrobial  therapy  should  be  administered  within  60  minutes  prior  to  surgical  incision  and  within  2  hours  if  vancomycin  or  a  fluoroquinolone  is  indicated.