RT Book, Section A1 Benjamin, John R. A2 Freeman, Brian S. A2 Berger, Jeffrey S. SR Print(0) ID 1135739532 T1 Strong Ion Difference T2 Anesthesiology Core Review: Part Two Advanced Exam YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259641770 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1135739532 RD 2024/10/08 AB A strong ion describes the complete dissociation of a molecule in solution. Its clinical application explains the acid–base abnormality associated with administration of intravenous normal saline crystalloid fluids. Understanding how strong ion chemistry affects blood pH is essential in understanding nongap metabolic acidosis. Many clinicians feel that this approach to understanding acid-base disorders is more complete that using the more traditional Henderson–Hasslebach method. Peter Stewart first popularized this approach in 1981 by the publication of his textbook and two years later in a journal article.