TY - CHAP M1 - Book, Section TI - Glycemic Control A1 - Preiser, Jean-Charles A1 - Ichai, Carole A2 - Hall, Jesse B. A2 - Schmidt, Gregory A. A2 - Kress, John P. PY - 2015 T2 - Principles of Critical Care, 4e AB - The physiological regulation of blood glucose involves hormonal and neural mechanisms, resulting in a control of glucose flux across cell membranes.High glucose concentrations are associated with cellular toxicity.Stress hyperglycemia is a marker of severity of illness.Intensive insulin therapy used to tightly control blood sugar was found beneficial in one single-center study, but not in seven independent other prospective trials.Current recommendations advocate a moderate glucose control by insulin therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1107715788 ER -