TY  - CHAP
M1  - Book, Section
TI  - Anesthetic Clinical Pharmacology in Pediatric Patients
A1  - Lu, Jeffrey K.
A2  - Johnson, Ken B.
PY  - 2015
T2  - Clinical Pharmacology for Anesthesiology
AB  - A  common  misconception  of  dosing  anesthetics  in  pediatric  patients  is  that  children  are  miniature  adults.  Although  there  are  substantial  physiologic  changes  with  early  development  and  maturation  (Table  21–1;  Figures  21–1  through  21–3),1-6  they  are  not  rigorously  accounted  for  in  published  dosing  guidelines  for  pediatric  patients.  Ideally,  dosing  recommendations  would  be  based  on  studies  in  children  at  various  phases  of  maturation  and  characterize  drug  kinetic  and  dynamic  behavior  as  a  function  of  age  and  body  composition.  Without  a  scientific  basis,  anesthesiologists  are  left  to  make  assumptions  and  educated  guesses  when  formulating  a  dosing  regimen  and  then  rely  on  the  forgiving  nature  of  most  anesthetics  that  have  a  wide  therapeutic  margin.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1103964514
ER  -