TY - CHAP M1 - Book, Section TI - Implications of Obesity on Anesthetic Drug Behavior A1 - Thackeray, Elizabeth M. A1 - Brewer, Lara A1 - Johnson, Ken B. A2 - Johnson, Ken B. PY - 2015 T2 - Clinical Pharmacology for Anesthesiology AB - Adverse physiologic changes in obese patients (Table 20–1) present multiple challenges in the operating room, including intravenous line placement, airway management, positioning, surgical exposure, and blood glucose control.10 Perhaps most important is determining the appropriate dose of anesthetic, as it will impact airway management and extubation and pain management. Although manufacturer's dosing recommendations are weight-normalized (mg/kg), obese patients are often excluded from clinical trials during drug development.9 Anesthesiologists rarely use total body weight (TBW) when programming an infusion pump or administering an induction dose for fear of an overdose; they often use something less than TBW to get “close enough” to the desired effect while avoiding significant adverse effects.11,12 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1103964413 ER -