TY - CHAP M1 - Book, Section TI - Carbon Dioxide Transport A1 - Winn, Andrew A1 - Freeman, Brian S. A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. PY - 2014 T2 - Anesthesiology Core Review: Part One Basic Exam AB - In the human body, carbon dioxide (CO2) is a metabolic waste product of aerobic metabolism. Specifically, two catabolic processes, pyruvate decarboxylation and the Kreb’s cycle, both of which occur in the mitochondria of cells, produce CO2. As a result of these processes, the concentration of CO2 increases proportionally to metabolic activity within tissues, leading to an increased partial pressure of carbon dioxide (Pco2). This pressure gradient drives CO2, a highly lipid-soluble molecule, out of tissues, across cell membranes, and into the blood of systemic capillaries. Once it has diffused into the capillaries, CO2 is transported to the lungs by three mechanisms. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1102569179 ER -