TY  - CHAP
M1  - Book, Section
TI  - Drug Termination of Action
A1  - Vashishta, Rishi
A1  - Berrigan, Michael J.
A2  - Freeman, Brian S.
A2  - Berger, Jeffrey S.
PY  - 2014
T2  - Anesthesiology Core Review: Part One Basic Exam
AB  - Exposure  to  xenobiotics  immediately  initiates  a  cascade  to  remove  the  foreign  compound  from  the  body’s  circulation.  The  elimination  of  many  drugs  begins  with  a  first  pass  effect,  where  orally  administered  drugs  absorbed  from  the  gastrointestinal  tract  into  circulation  pass  through  the  liver  before  reaching  targeted  sites  of  action.  Although  the  liver  and  kidneys  are  used  to  clear  most  compounds,  other  organs,  including  the  skin  and  lungs,  also  assist  with  clearance.  In  most  cases,  the  drug  action  terminates  by  enzyme-catalyzed  conversion  to  inactive  (or  less  active)  compounds  and/or  elimination  via  the  kidneys  or  other  routes.  Drug  redistribution  from  the  primary  site  may  also  terminate  the  action,  although  this  occurs  infrequently.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1102566824
ER  -