TY - CHAP M1 - Book, Section TI - Protein C Deficiency A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Marciniak, Bruno A1 - Dalens, Bernard J. PY - 2006 T2 - Syndromes: Rapid Recognition and Perioperative Implications AB - Congenital or acquired control of the clotting mechanism resulting in a widespread thrombotic tendency. Protein C is a vitamin K-dependent serine protease zymogen that selectively inhibits factors Va and VIII:C in human plasma, and thus has an important anticoagulant role. It is associated with an increased tendency to thrombosis. It is either inherited or acquired: bacterial sepsis (especially of meningococcal origin), hepatic disease, disseminated intravascular coagulation, l-asparaginase therapy, nephrotic syndrome, conditioning therapy in bone marrow transplantation, warfarin-induced skin lesions. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/15 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=58084033 ER -