TY  - CHAP
M1  - Book, Section
TI  - Chapter 4. The Role of Genomics in Anesthesia Practice
A1  - Podgoreanu, Mihai V.
A1  - Kertai, Miklos D.
A2  - Longnecker, David E.
A2  - Brown, David L.
A2  - Newman, Mark F.
A2  - Zapol, Warren M.
PY  - 2012
T2  - Anesthesiology, 2e
AB  - Hundreds  of  genome-wide  association  studies  have  been  performed  in  recent  years  to  identify  common  variants  that  are  associated  with  complex  disease.  Although  there  have  been  some  notable  success  stories,  overall  common  variation  has  explained  little  of  the  high  heritability  of  these  traits.  It  is  likely  that  the  use  of  whole-genome  sequencing  to  extend  the  study  of  rare  variation  in  complex  diseases  will  greatly  advance  our  understanding  of  perioperative  biology.Preliminary  candidate  gene  studies  suggest  that  susceptibility  to  adverse  perioperative  events,  including  cardiac  (myocardial  infarction  [MI],  ventricular  dysfunction,  atrial  fibrillation),  neurologic,  and  renal,  among  others,  is  genetically  determined.Potential  applications  of  biomarkers  in  perioperative  medicine  and  critical  care  include  prognosis,  diagnosis,  and  monitoring  of  adverse  outcomes,  as  well  as  informing  and  refining  therapeutic  decisions.  Very  few  so  far  have  been  rigorously  evaluated  to  demonstrate  additive  performance  to  existing  risk  stratification  models  (clinical  validity)  or  change  therapy  (clinical  utility).  Most  promising  among  those  are  natriuretic  peptides  and  C-reactive  protein  for  cardiovascular  risk  prediction,  and  procalcitonin  to  assess  infection  in  the  critically  ill.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=56620598
ER  -