TY  - CHAP
M1  - Book, Section
TI  - Drug Dosing and Monitoring in the Critically Ill and Injured Patient
A1  - Bauer, Seth R.
A1  - Dzierba, Amy L.
A2  - Schmidt, Gregory A.
A2  - Kress, John P.
A2  - Douglas, Ivor S.
PY  - 2023
T2  - Hall, Schmidt and Wood’s Principles of Critical Care, 5<sup>th</sup> Edition
AB  - KEY  POINTSMedication  dosages  are  typically  titrated  to  the  intended  effect,  with  an  intravenous  administration  strategy  selected  based  on  the  medication  properties  and  goals  of  therapy.Drug  volume  of  distribution  is  often  increased  in  critically  ill  patients  necessitating  the  use  of  initial  loading  doses  to  quickly  achieve  therapeutic  drug  concentrations.Pharmacokinetic  changes  evolve  throughout  a  patient’s  illness  course  requiring  frequent  reassessment  and  refinement  of  dosage  regimens.Therapeutic  drug  monitoring  can  improve  dosage  optimization  but  should  be  reserved  for  patient  populations  with  significant  pharmacokinetic  variability.Patients  with  acute  kidney  injury  should  have  initial  normal  (nonadjusted)  medication  dosage  regimens  with  subsequent  modification  based  on  renal  injury  progression,  including  the  initiation  or  cessation  of  continuous  renal  replacement  therapy.Clinicians  should  thoroughly  evaluate  each  medication  during  transitions  of  care  in  order  to  stop  unnecessary  therapies.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/10/15
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1201812089
ER  -