TY - CHAP M1 - Book, Section TI - Novel Modes of Mechanical Ventilation A1 - Al-Hegelan, Mashael A1 - MacIntyre, Neil R. A2 - Schmidt, Gregory A. A2 - Kress, John P. A2 - Douglas, Ivor S. PY - 2023 T2 - Hall, Schmidt and Wood’s Principles of Critical Care, 5th Edition AB - KEY POINTSMechanical ventilators are support devices, not therapeutic devices. The clinical goal is thus to support gas exchange without causing harm.A number of challenges face clinicians in providing safe and effective mechanical ventilatory support. Three of the most important are: (1) supporting gas exchange without causing injury from applied pressure or FiO2; (2) providing comfortable interactive support; (3) facilitating the discontinuation process as the lung recovers.Innovations need to focus on addressing clinical challenges and improve important clinical outcomes.Over the past quarter century, innovations that have generated considerable clinical interest include airway pressure release ventilation, high-frequency ventilation, feedback controls on variable flow-pressure-targeted breaths, proportional assist ventilation, and neutrally adjusted ventilatory assistance.While all of these innovations have conceptual appeal and supporting observational data, none as yet has convincing randomized control trial data, demonstrating improved clinical outcomes. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/09/12 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1201803057 ER -