TY - CHAP M1 - Book, Section TI - The Blood-Brain Barrier and Its Influence on Drug Transport to the Brain A1 - Daneman, Richard A1 - Hammarlund-Udenaes, Margareta A1 - Shusta, Eric V. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - AbbreviationsApo: apolipoproteinATP: adenosine triphosphateAUC: area under the concentration-time curveBBB: blood-brain barrierBCRP: breast cancer resistance proteinBCSFB: blood–cerebrospinal fluid barrierCSF: cerebrospinal fluidfu,brain: unbound fraction of drug in brain homogenatefu,plasma: unbound fraction of drug in plasmaFUS: focused ultrasoundIR: insulin receptorISF: interstitial fluidKp,uu,brain: partition coefficient of unbound drug in brain interstitial fluid to that in plasmaKp,uu,cell: partition coefficient of unbound drug between intracellular and interstitial fluidsLDLRf: low-density lipoprotein receptor familyMRP: multidrug resistance proteinPET: positron emission tomographyPS: permeability surface area productRMT: receptor-mediated transcytosisTf: transferrinTfR: transferrin receptorVu,brain: unbound volume of distribution in the brain; i.e., partitioning of total drug to that unbound in the brain interstitial fluid SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/07 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1193229282 ER -