TY - CHAP M1 - Book, Section TI - Pharmacodynamics: Molecular Mechanisms of Drug Action A1 - Manning, David R. A1 - Blumenthal, Donald K. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - AbbreviationsAC: adenylyl cyclaseACE: angiotensin-converting enzymeACh: acetylcholineAKAP: A-kinase anchoring proteinAMPA: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acidAMPK: AMP-activated protein kinaseAngII: angiotensin IIANP: atrial natriuretic peptideAP-1: activator protein-1 (transcription factor)Apaf-1: apoptotic activating protease factor 1ATG: autophagy geneAT1R: angiotensin subtype 1 receptorBNP: brain natriuretic peptideCaM: calmodulinCAR: constitutive androstane receptorCNP: C-type natriuretic peptideCYP: cytochrome P450DAG: diacylglycerolDHFR: dihydrofolate reductaseEC50: half-maximally effective concentrationED50: half-maximally effective doseEGF: epidermal growth factoreNOS: endothelial NOS (NOS3)EPAC: exchange protein activated by cyclic AMPER: endoplasmic reticulumFBP: fructose 1,6-bisphosphateFXR: farnesoid X receptorGABA: γ-aminobutyric acidGC: guanylyl cyclaseGEF: guanine nucleotide exchange factorGnRH: gonadotropin-releasing hormoneGPCR: G protein-coupled receptorGRK: GPCR kinaseHMG-CoA: hydroxymethylglutaryl–coenzyme AHRE: hormone response element5HT: 5-hydroxytryptamine (serotonin)IFN: interferonIL: interleukiniNOS: inducible NOS (NOS2)IP3: inositol 1,4,5-trisphosphateJAK: Janus kinaseJNK: c-Jun N-terminal kinaseKi: affinity of a competitive antagonistKir: inward rectifying K+ channelLD50: half-maximal lethal doseLKB1: liver kinase B1LXR: liver X receptorMAPK: mitogen-activated protein kinaseMLCK: myosin light chain kinasemTOR: mechanistic or mammalian target of rapamycin, a protein kinasemTORC: mechanistic or mammalian target of rapamycin complexNAM: negative allosteric modulatorNE: norepinephrineNF-κB: nuclear factor-κBNMDA:N-methyl-D-aspartatenNOS: neuronal NOSNO: nitric oxideNOS: NO synthaseNPR: natriuretic peptide receptorNSAID: nonsteroidal anti-inflammatory drugPAMP: pathogen-associated molecular patternPDE: cyclic nucleotide phosphodiesterasePAM: positive allosteric modulatorPDGF: platelet-derived growth factorPI3K: phosphatidylinositol 3-kinasePIP2: phosphatidylinositol 4,5-bisphosphatePK: protein kinase, e.g., PKA, PKB (also known as Akt), PKCPLC: phospholipase CPPAR: peroxisome proliferator-activated receptorPTB: phosphotyrosine-bindingPXR: pregnane X receptorRAR: retinoic acid receptorRGS: regulator of G protein signalingRhoGEF: RhoA guanine nucleotide exchange factorRIP1: receptor interacting protein 1ROCK: Rho-associated protein kinaseRXR: retinoid X receptorSERM: selective estrogen receptor modulatorsGC: soluble guanylyl cyclaseSH2: Src homology 2SMAC: second mitochondria-derived activator of caspaseSMN1: survival motor neuron proteinSTAT: signal transducer and activator of transcriptionTGF-β: transforming growth factor βTLR: toll-like receptorTNF-α: tumor necrosis factor αTNFR: TNF-α receptorTOR: target of rapamycinTRAIL: TNF-related apoptosis-inducing ligandTRP: transient receptor potentialVEGF: vascular endothelial growth factorVSMC: vascular smooth muscle cell SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/10 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1193226677 ER -