TY  - CHAP
M1  - Book, Section
TI  - Thrombosis and Transfusions
A1  - Dulu, Alina
A1  - Akella, Padmastuti
A1  - Serhan, Mustapha
A1  - Pastores, Stephen M.
A2  - Go, Ronaldo C.
PY  - 2022
T2  - Understanding Crisis in Critical Care
AB  - There  is  increasing  evidence  that  the  activation  of  coagulation  and  inflammation  are  essential  responses  for  host  defense  during  critical  illnesses  such  as  sepsis,  severe  trauma,  and  in  the  current  era  of  pandemic  respiratory  viruses.  Venous  thromboembolism  (VTE),  pulmonary  microvascular  thrombosis,  and  arterial  thrombosis  have  been  associated  with  influenza  A  virus  and  most  recently  with  the  severe  acute  respiratory  syndrome-coronavirus-2  (SARS-CoV-2).  Similarly,  there  have  been  significant  advances  in  transfusion  medicine  with  the  establishment  of  appropriate  thresholds  for  blood  product  support  in  critically  ill  patients,  enhanced  understanding  of  transfusion-related  complications,  and  use  of  blood  alternatives.  This  chapter  will  discuss  the  pathophysiology  of  thrombosis  during  critical  illness,  and  review  the  thrombotic  complications  and  issues  surrounding  anticoagulation  management  particularly  in  patients  with  coronavirus  disease-19  (COVID-19)  and  anticoagulant  reversal  agents.  Indications  for  red  blood  cell,  platelet,  and  plasma  transfusion  in  critically  ill  and  trauma  patients  will  be  reviewed  as  well  as  the  indications  for  massive  transfusion,  complications  of  blood  product  support,  and  strategies  to  minimize  blood  loss  and  optimize  hematopoiesis.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1184737645
ER  -