TY - CHAP M1 - Book, Section TI - Continuous Peripheral Nerve Blocks A1 - Hadzic, Admir PY - 2021 T2 - Hadzic's Peripheral Nerve Blocks and Anatomy for Ultrasound-Guided Regional Anesthesia, 3e AB - The analgesic efficacy of single-injection peripheral nerve blocks (PNBs) is limited to 8 to 24 hours. A longer duration of analgesia is often desirable, but the options are limited. For the interscalene brachial plexus block, liposome bupivacaine (Exparel) has been approved by the US Food and Drug Administration (FDA) as single-injection analgesia for up to 72 hours. As of April 2021, Exparel is now also approved in EU for interscalane and femoral nerve blocks as well. A longer duration of analgesia can also be accomplished with a continuous infusion of local anesthetic (LA) via a perineurally placed catheter. This method requires a high degree of skill and management, but the equipment is usually available worldwide. Continuous peripheral nerve blocks (CPNBs) are utilized for a wide variety of indications, most typically for anesthesia or analgesia in an increasing number of clinical indications, also as fascial sheath catheters (e.g., pectoralis, erector spinae infusions). The majority of reported applications of CPNBs relate to the treatment of perioperative pain. While there are reports on their new applications, many of the increasing numbers of proposed catheter infusions lack clear evidence-based information on their efficacy. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1183901857 ER -