TY - CHAP M1 - Book, Section TI - Clinical Pharmacology of Local Anesthetics A1 - Butterworth IV, John A2 - Hadzic, Admir PY - 2017 T2 - Hadzic's Textbook of Regional Anesthesia and Acute Pain Management, 2e AB - Local and regional anesthesia and analgesia appear to be under going a renaissance, as judged by attendance at specialty meetings and substantial increase in research activity, as evidenced by growing number of scientific publications. In contrast to general anesthesia, in which the molecular mechanism remains the subject of speculation, the site at which local anesthetic (LA) drugs bind to produce nerve blocks has been cloned and mutated. This chapter focuses on mechanisms of anesthesia and toxicity, especially as knowledge of these mechanisms will assist the clinician in conducting safer and more effective regional anesthesia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1141731075 ER -