TY - CHAP M1 - Book, Section TI - Continuous Venovenous Hemofiltration A1 - Manasia, Anthony A1 - Hidalgo, Renzo H. A2 - Oropello, John M. A2 - Pastores, Stephen M. A2 - Kvetan, Vladimir PY - 1 T2 - Critical Care AB - KEY POINTSUnderstanding the fundamental principles of continuous venovenous hemofiltration (CVVH), how it differs from hemodialysis, and its use in the critically ill patient is essential for all intensivists.CVVH should be the intensivist’s first choice as renal replacement therapy for any intensive care unit (ICU) patient with hemodynamic instability.Continuous renal replacement therapy (CRRT) is most often prescribed based on body weight to an effluent flow rate target of 20 to 25 mL/kg/h. Effluent flow rates higher than 25 mL/kg/h do not improve outcomes in ICU patients.Anticoagulation is generally recommended, as the clotting cascades are activated when the blood interfaces with the nonendothelial surfaces of the tubing and filter.Administration of replacement fluid (RF) maintains fluid balance and lowers the plasma concentration of solute by dilution. Typical RF rates are 1000 to 2000 mL/h. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1136419757 ER -