TY - CHAP M1 - Book, Section TI - Soft Tissue Infections A1 - Conly, John A2 - Hall, Jesse B. A2 - Schmidt, Gregory A. A2 - Kress, John P. Y1 - 2015 N1 - T2 - Principles of Critical Care, 4e AB - Soft tissue infections characterized by extensive necrosis of subcutaneous tissue, fascia, or muscle are uncommon, but they require prompt recognition and urgent surgical treatment.The classic hallmarks of necrotizing soft tissue infections are extensive involvement of the subcutaneous tissues and a relative paucity of cutaneous involvement until late in the course of the infection.Rapidly spreading soft tissue infections present acutely with severe systemic toxicity.Successful management of these critically ill patients depends on prompt diagnosis by clinical and radiologic means.The principles of management include fluid resuscitation, hemodynamic stabilization, a broad-spectrum antimicrobial regimen, and early surgical intervention.Prompt surgery, in which a definitive diagnosis is reached and all necrotic tissue is debrided, should be considered the mainstay of treatment.The mortality rate is highest when the diagnosis is delayed or initial surgical treatment is limited. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1107721157 ER -