TY - CHAP M1 - Book, Section TI - Leigh Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Marciniak, Bruno A1 - Dalens, Bernard J. Y1 - 2006 N1 - T2 - Syndromes: Rapid Recognition and Perioperative Implications AB - Severe progressive necrotizing encephalopathy occurring between the age of 3 months and 2 years. Caused by a mitochondrial disorder impeding oxidative phosphorylation. Symptoms include loss of previously acquired motor skills, muscle weakness, hypotonia, lactic acidosis associated with respiratory and kidney dysfunction. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=58073928 ER -