TY - CHAP M1 - Book, Section TI - Chapter 85. Protection of the Central Nervous System in Surgical Patients A1 - Kofke, Andrew A2 - Longnecker, David E. A2 - Brown, David L. A2 - Newman, Mark F. A2 - Zapol, Warren M. Y1 - 2012 N1 - T2 - Anesthesiology, 2e AB - The incidence of perioperative stroke without predisposing factors is approximately 0.1%, but specific risk factors and procedures can increase the risk by 10-fold or more.Cerebrovascular reserve refers to the capability of the brain's vasculature to dilate in order to compensate for perioperative physiologic stresses.Attention to the maintenance of a normal physiologic milieu is the first principle of brain-oriented perioperative care.Fever kills vulnerable neurons, and hypothermia is protective in cases of cardiac arrest and possibly traumatic brain injury.Glycemic control improves outcome after severe critical illness and probably optimizes neurologic outcome.Some anesthetics are neuroprotective, but some anesthetic drugs may have neurotoxic potential. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=56655557 ER -