TY - CHAP M1 - Book, Section TI - Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination A1 - Buxton, Iain L. O. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. Y1 - 2023 N1 - T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - The human body restricts access to foreign molecules; therefore, to reach its target within the body and have a therapeutic effect, a drug molecule must cross several restrictive barriers en route to its target site. Following administration, the drug must be absorbed and distributed, usually via vessels of the circulatory and lymphatic systems. In addition to crossing membrane barriers, the drug must survive metabolism (primarily hepatic) and elimination (by the kidney and liver and in the feces). ADME, the absorption, distribution, metabolism, and elimination of drugs, are the processes of pharmacokinetics (Figure 2–1). Understanding these processes and their interplay and employing pharmacokinetic principles increase the probability of therapeutic success and reduce the occurrence of adverse drug events and drug-drug interactions. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1193226397 ER -