TY - CHAP M1 - Book, Section TI - Hemostasis and Hemotherapy A1 - Hall, Stanley M. A1 - McDonough, Kathleen H. A2 - Levitzky, Michael A2 - McDonough, Kathleen A2 - Kaye, Alan David A2 - Hall, Stanley Y1 - 2021 N1 - T2 - Clinical Physiology in Anesthetic Practice AB - Hemostasis is the process of preventing the loss of blood when a blood vessel is injured. The platelets or thrombocytes, as discussed in the previous chapter, play an integral role in hemostasis when they are activated and begin clustering together or aggregating. In addition, vasoconstriction of the injured blood vessel decreases blood flow through the injured site such that a clot can form and not be dislodged. Vasoconstriction also decreases the amount of blood that could leak from the injured vessel. The final step in hemostasis is the formation of a permanent clot through activation of the multistep clotting mechanisms involving the formation of interwoven fibrin plugs which trap platelets and blood cells. Eventually scar formation and endothelialization will permanently repair the vessel and the clot will be reabsorbed. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/20 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1175534032 ER -