TY - CHAP M1 - Book, Section TI - Ethanol A1 - Mihic, S. John A1 - Koob, George F. A1 - Mayfield, Jody A1 - Harris, R. Adron A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. Y1 - 2017 N1 - T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol that directly affects many different types of neurochemical systems and signaling cascades and has rewarding and addictive properties. It is the oldest recreational drug and likely contributes to more morbidity, mortality, and public health costs than all illicit drugs combined. The current Diagnostic and Statistical Manual of Mental Disorders (DSM-5) integrates alcohol abuse and alcohol dependence into a single disorder called alcohol use disorder (AUD), with mild, moderate, and severe subclassifications (American Psychiatric Association, 2013). This chapter presents an overview of the effects of ethanol on various physiological systems, then focuses on the mechanisms of ethanol’s effects in the CNS as the basis for understanding the rewards, disease processes, and treatments for ethanol-related conditions. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/15 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1162537223 ER -