TY - CHAP M1 - Book, Section TI - High-Frequency Oscillatory Ventilation A1 - Duff, Michael A1 - Pastores, Stephen M. A2 - Oropello, John M. A2 - Pastores, Stephen M. A2 - Kvetan, Vladimir Y1 - 1 N1 - T2 - Critical Care AB - KEY POINTSHigh-frequency oscillatory ventilation (HFOV) is a form of ventilatory support which delivers very small tidal volumes (1-2 ml per kg) at very high rates (3-15 breaths per second).The major indication for HFOV is for patients with severe acute respiratory distress syndrome (ARDS) whose lungs cannot tolerate high tidal distending pressure.The main determinant of oxygenation during HFOV is the mPaw which is generally initiated at approximately 5 cm H2O greater than the mPaw noted during conventional ventilation.Carbon dioxide removal during HFOV is directly propportional to the oscillation amplitude and inversely proportional to the oscillation frequency setting.Two recent multicenter randomized trials showed no benefit (OSCAR) and even harm (OSCILLATE) with the use of HFOV in adult patients with ARDS. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/10 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1136419788 ER -