TY - CHAP M1 - Book, Section TI - Acute Kidney Injury and Failure A1 - Patel, Pritul A1 - Hosseinian, Leila A2 - Oropello, John M. A2 - Pastores, Stephen M. A2 - Kvetan, Vladimir Y1 - 1 N1 - T2 - Critical Care AB - KEY POINTSCurrent concepts of AKI in sepsis indicate that systemic inflammation, microvascular dysregulation, and mitochondrial alteration, leading to cell death may be more important than global renal hypoperfusion.Urine output and SCr are at best surrogate markers of renal function, but can be “normal” in the presence of renal dysfunction.Recent studies have identified new biomarkers of renal injury that can diagnose AKI earlier than SCr, but these are still in the primary stages of clinical adoption.Prevention of contrast-induced AKI focuses on the use of noniodinated contrast media, minimizing contrast-media volume, avoiding repeat exposure to contrast media, and expanding plasma volume before administration of contrast media.The published literature suggests that periprocedural dialysis has no protective effect against CI-AKI. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/05 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1136414640 ER -