TY - CHAP M1 - Book, Section TI - Antibiotics A1 - Lee, Angela A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. Y1 - 2016 N1 - T2 - Anesthesiology Core Review: Part Two Advanced Exam AB - Surgical site infections (SSIs) occur within 30 days of surgery or within 90 days if a prosthetic implant. Antibiotic prophylaxis reduces microorganisms at the operative site during surgery. Cefazolin is the drug of choice for many surgeries because it is effective against streptococcus, methicillin susceptible staphylococci, and some gram-negative bacteria. Second-generation cephalosporins have broader coverage against gram-negative organisms than cefazolin. Cefoxitin and cefotetan also cover some anaerobes. The role of vancomycin in SSI prophylaxis is in the methicillin-resistant staphylococci colonized patient. Antimicrobial therapy should be administered within 60 minutes prior to surgical incision and within 2 hours if vancomycin or a fluoroquinolone is indicated. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1135743809 ER -