TY - CHAP M1 - Book, Section TI - Hemoglobinopathies A1 - Nguyen, Vinh A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. Y1 - 2016 N1 - T2 - Anesthesiology Core Review: Part Two Advanced Exam AB - The red blood cell is a vehicle that utilizes hemoglobin to facilitate the delivery of oxygen to vital organs or tissue. Hemoglobin is a tetrameric protein composed of two α- and two β-molecules. Hemoglobinopathies are a result of various types of mutation within either the α or β genes. This mutation affects transcription, translation, and ultimately protein formation. The mutated globin proteins lead to the lack of production, deletion, or dysfunctional hemoglobin subunits. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1135741286 ER -