TY - CHAP M1 - Book, Section TI - Strong Ion Difference A1 - Benjamin, John R. A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. Y1 - 2016 N1 - T2 - Anesthesiology Core Review: Part Two Advanced Exam AB - A strong ion describes the complete dissociation of a molecule in solution. Its clinical application explains the acid–base abnormality associated with administration of intravenous normal saline crystalloid fluids. Understanding how strong ion chemistry affects blood pH is essential in understanding nongap metabolic acidosis. Many clinicians feel that this approach to understanding acid-base disorders is more complete that using the more traditional Henderson–Hasslebach method. Peter Stewart first popularized this approach in 1981 by the publication of his textbook and two years later in a journal article. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1135739532 ER -