TY - CHAP M1 - Book, Section TI - Controlled Hypothermia A1 - Diallo, Mofya S. A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. Y1 - 2016 N1 - T2 - Anesthesiology Core Review: Part Two Advanced Exam AB - Controlled hypothermia is indicated for neuroprotection after cardiac arrest, neonatal asphyxia, and neonatal encephalopathy, with improved outcome in the intensive care unit setting. It has been shown that decreasing core temperature is protective when there is a risk of ischemia and hypoxia. The brain has high metabolic demands, requiring a constant glucose and oxygen supply, which make it highly vulnerable to injury. Hypothermia is applied intraoperatively in neurosurgical and cardiac surgeries, both of which are associated with high risk of tissue hypoxia and ischemia. Cardiac surgery requiring cardiopulmonary bypass (CPB) exposes multiple organ systems, including the brain, to the risk of hypoxia and ischemia. Hypothermia during CPB reduces whole body oxygen consumption. However, routine application of induced hypothermia continues to be controversial. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1135738735 ER -