TY  - CHAP
M1  - Book, Section
TI  - Histamine, Bradykinin, and Their Antagonists
A1  - Skidgel, Randal A.
A1  - Kaplan, Allen P.
A1  - Erdös, Ervin G.
A2  - Brunton, Laurence L.
A2  - Chabner, Bruce A.
A2  - Knollmann, Björn C.
Y1  - 2015
N1  - 
T2  - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
AB  - The  biogenic  amine,  histamine,  is  a  major  mediator  of  inflammation,  anaphylaxis,  and  gastric  acid  secretion;  in  addition,  histamine  plays  a  role  in  neurotransmission.  Our  understanding  of  the  physiological  and  pathophysiological  roles  of  histamine  has  been  enhanced  by  the  development  of  subtype-specific  receptor  antagonists  and  by  the  cloning  of  four  receptors  for  histamine.  Competitive  antagonists  of  H1  receptors  have  diverse  actions  and  are  used  therapeutically  in  treating  allergies,  urticaria,  anaphylactic  reactions,  nausea,  motion  sickness,  insomnia,  and  some  symptoms  of  asthma.  Antagonists  of  the  H2  receptor  are  effective  in  reducing  gastric  acid  secretion.  The  peptide,  bradykinin,  has  cardiovascular  effects  similar  to  those  of  histamine  and  plays  prominent  roles  in  inflammation  and  nociception.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2023/09/25
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1127868342
ER  -