TY - CHAP M1 - Book, Section TI - Anesthetic Considerations for Liver Transplant A1 - Galaviz, Charles A2 - Johnson, Ken B. PY - 2015 T2 - Clinical Pharmacology for Anesthesiology AB - The liver plays a wide variety of roles in the overall scheme of the normal physiology of the body. The liver is involved in many aspects of metabolism, such as (1) lipid metabolism through fatty acid synthesis and lipoprotein conversion and (2) carbohydrate metabolism via glycogen storage, release. It is also the site of gluconeogenesis and amino acid metabolism. The liver is involved in synthesis of important proteins such as albumin and some of the coagulation factors. It also plays a role in immune system response, filtering out toxins and bacteria from the gastrointestinal tract, as well as amplifying the immune response via immune cells present in the liver. In addition, the liver is involved in endocrine control, via synthesis and secretion of hormones such as insulin-like growth factor 1 and angiotensinogen, as well as through inactivation of hormones such as insulin and corticosteroids. The liver also plays a major role in the coagulation system via synthesis of proclotting and anticlotting factors. Finally, it functions in modulating blood volume, acting as a reservoir for blood volume that can then be released into the bloodstream when stimulated by the sympathetic nervous system.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1103965152 ER -