TY - CHAP M1 - Book, Section TI - Anesthetic Considerations During Cardiopulmonary Bypass A1 - Gmelch, Ben A2 - Johnson, Ken B. PY - 2015 T2 - Clinical Pharmacology for Anesthesiology AB - Cardiothoracic surgery entails unique, often extreme, conditions in comparison to noncardiac surgery. Profound hemodynamic and physiologic perturbations associated with hypothermic cardiopulmonary bypass (CPB) and circulatory arrest lead to unique dosing considerations for anesthetic drugs, anticoagulants, vasoactives, inotropes, and antifibrinolytics. This chapter will review the pharmacologic considerations of cardiac anesthesia chronologically in stages, from premedication and induction to pre-CPB maintenance, initiation of CPB, separation from CPB, and the post-CPB period. A special discussion will review the unique pharmacologic approach to anticipated deep hypothermic circulatory arrest (DHCA). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/12 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1103964985 ER -