TY - CHAP M1 - Book, Section TI - Importance and Limitations of Simulation in Clinical Pharmacology A1 - Johnson, Ken B. A1 - Tams, Carl A2 - Johnson, Ken B. PY - 2015 T2 - Clinical Pharmacology for Anesthesiology AB - Anesthesiologists use many potent drugs either as single agents or in combination. Each of these drugs has a unique profile in terms of how their concentrations and effects change over time and how they interact with other drugs. Although the basic features of anesthetic drugs are well established, the time course of how the drugs behave, especially in combination with other drugs, is complex and difficult to predict. Anesthesiologists rely on experience and training to formulate dosing regimens, yet they can be confounded by the dynamic changes encountered in the operating room and intensive care unit. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1103963306 ER -