TY - CHAP M1 - Book, Section TI - Pharmacokinetics, Biophase, and Pharmacodynamics and the Importance of Simulation A1 - Johnson, Ken B. A1 - Egan, Talmage D. A2 - Johnson, Ken B. PY - 2015 T2 - Clinical Pharmacology for Anesthesiology AB - When selecting an anesthetic, anesthetists often consider, among others, the questions presented in Table 1–1. To answer these questions, anesthetists turn to textbooks, journal articles, and drug package inserts. These resources provide dosing recommendations (ie, bolus doses and infusion rates) and important features of anesthetic drugs but often fall short of providing useful answers. Anesthetists therefore rely on years of training and experience to formulate the correct dose and safely administer it. Experienced anesthetists develop a sense of how individual drugs behave and can easily tailor them to meet the needs of their patients. For example, anesthetists have a good “feel” for what a 3-mL (150 mcg) intravenous bolus of fentanyl will accomplish in a healthy adult and can accurately predict the onset and duration of analgesic effect. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/10 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1103962917 ER -