TY  - CHAP
M1  - Book, Section
TI  - Antagonism of Neuromuscular Blockade
A1  - Lewis, Choy R.A.
A2  - Freeman, Brian S.
A2  - Berger, Jeffrey S.
PY  - 2014
T2  - Anesthesiology Core Review: Part One Basic Exam
AB  - Muscle  relaxation  caused  by  a  muscle  relaxant  drug  can  be  terminated  spontaneously  by  diffusion,  redistribution,  metabolism,  and  excretion  or  via  pharmacological  antagonism  using  specific  reversal  agents  known  as  cholinesterase  inhibitors.  Acetylcholinesterase  is  an  enzyme  found  at  the  motor  end  plate.  It  functions  by  breaking  down  and  reducing  the  amount  of  acetylcholine  (ACh)  at  the  nerve  terminal.  By  inhibiting  acetylcholinesterase,  cholinesterase  inhibitors  indirectly  increase  the  amount  of  ACh  molecules  that  are  available  to  compete  with  the  nondepolarizing  muscle  relaxant  for  the  binding  sites  of  the  ACh  receptors.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1102567285
ER  -