TY - CHAP M1 - Book, Section TI - Minimum Alveolar Concentration A1 - Nguyen, Vinh A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. PY - 2014 T2 - Anesthesiology Core Review: Part One Basic Exam AB - The concept of minimum alveolar concentration (MAC) was first introduced by Dr. Edmund Eger in 1965. Prior to this time, there was no accurate way to measure the anesthetic potencies or adequate dosing. Earlier methods focused on the assessment of clinical signs, such as pupil diameter, eyelid reflex, and lacrimation during the different stages of anesthesia. Compared to the limitations associated with these signs, the principle of MAC targets a single clinical end point: immobility in response to surgical stimulus. MAC is defined as the minimum alveolar concentration of inhaled anesthetic at sea level required to suppress movement to a surgical incision in 50% of the patients. It is often referred to as the ED50 for immobility, MAC-movement, or median alveolar concentration. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1102566954 ER -