TY - CHAP M1 - Book, Section TI - Chapter 210. Diabetic Ketoacidosis A1 - Patel, Krunal A1 - Kohli-Seth, Roopa A2 - Atchabahian, Arthur A2 - Gupta, Ruchir PY - 2013 T2 - The Anesthesia Guide AB - DKA is defined by a lack of insulin or an excess of hyperglycemic hormones leading to an inability by the tissues to use glucose. This leads to lipolysis and the synthesis of ketoacids that will be used as fuel. Ketoacids will trigger metabolic acidosis and polyuria leading to severe dehydrationTriggering factors: Inaugural in DM1 (common, revealing about 10% of DM1) or DM2 (rare)Noncompliance or iatrogenic (inadequate insulin coverage, steroids, beta-agonists)Infection or inflammation (e.g., pneumonia, UTI, foot ulcer, abdominal [appendicitis, cholecystitis, pancreatitis, etc.])MIPregnancyTraumaMortality in DKA is primarily due to the underlying precipitating illness and only rarely due to the metabolic complications of hyperglycemia or ketoacidosis. The prognosis of DKA is substantially worse at the extremes of age and in the presence of coma and hypotensionDKA can present as severe, pseudosurgical abdominal pain. Accurate diagnosis will prevent unnecessary surgery SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=57263750 ER -