TY - CHAP M1 - Book, Section TI - Chapter 4. The Role of Genomics in Anesthesia Practice A1 - Podgoreanu, Mihai V. A1 - Kertai, Miklos D. A2 - Longnecker, David E. A2 - Brown, David L. A2 - Newman, Mark F. A2 - Zapol, Warren M. PY - 2012 T2 - Anesthesiology, 2e AB - Hundreds of genome-wide association studies have been performed in recent years to identify common variants that are associated with complex disease. Although there have been some notable success stories, overall common variation has explained little of the high heritability of these traits. It is likely that the use of whole-genome sequencing to extend the study of rare variation in complex diseases will greatly advance our understanding of perioperative biology.Preliminary candidate gene studies suggest that susceptibility to adverse perioperative events, including cardiac (myocardial infarction [MI], ventricular dysfunction, atrial fibrillation), neurologic, and renal, among others, is genetically determined.Potential applications of biomarkers in perioperative medicine and critical care include prognosis, diagnosis, and monitoring of adverse outcomes, as well as informing and refining therapeutic decisions. Very few so far have been rigorously evaluated to demonstrate additive performance to existing risk stratification models (clinical validity) or change therapy (clinical utility). Most promising among those are natriuretic peptides and C-reactive protein for cardiovascular risk prediction, and procalcitonin to assess infection in the critically ill. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/08 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=56620598 ER -