TY - CHAP M1 - Book, Section TI - Hematopoietic Stem Cell Transplantation and Graft-Versus-Host Disease A1 - Fingrut, Warren A1 - Pastores, Stephen M. A1 - Rosenzweig, Michael A. A1 - Jakubowski, Ann A. A2 - Schmidt, Gregory A. A2 - Kress, John P. A2 - Douglas, Ivor S. PY - 2023 T2 - Hall, Schmidt and Wood’s Principles of Critical Care, 5th Edition AB - KEY POINTSThe complications of hematopoietic stem cell transplantation can impact any organ system and generally relate to the consequences of the cytoreductive therapy, infections, and in the case of allogeneic transplants, immunosuppression, and development of graft-versus-host disease (GVHD).GVHD remains one of the most important complications of allogeneic transplantation.Stem cell transplant recipients may require admission to the intensive care unit (ICU) for close monitoring for volume and electrolyte issues, vasopressor or renal support, and mechanical ventilation.The approach to the diagnosis and management of infectious disorders in the stem cell transplant recipient is dependent on the underlying disease and prior therapy, timing of the infection relative to the transplant, the type of transplant, and the patient’s immunologic history and comorbidities.Pulmonary complications develop in up to 60% of allogeneic transplant recipients and are the immediate cause of death in approximately half of the cases.Major noninfectious pulmonary complications in the early transplant period include idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, and peri-engraftment respiratory distress syndrome; bronchiolitis obliterans syndrome and bronchiolitis obliterans organizing pneumonia occur later.Despite advances in supportive care in the ICU, the mortality rate of allogeneic transplant recipients who develop respiratory failure and multiple organ failure remains extremely high. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/10/13 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1201808351 ER -