TY - CHAP M1 - Book, Section TI - Tranexamic Acid A1 - Hess, Philip E. A2 - Hess, Philip E. A2 - Li, Yunping A2 - Kowalczyk, John J. A2 - Stiles, Justin K. PY - 2023 T2 - Obstetric Anesthesia: Quick References & Practical Guides AB - Obstetric hemorrhage is the leading cause of maternal mortality worldwide. Despite active management during the third stage of labor, postpartum hemorrhage (PPH) remains a problem and is increasing in the United States, primarily due to the increasing incidence of atony.1 Tranexamic acid (TXA) is a lysine analogue and works by binding to plasminogen, thereby inhibiting fibrinolysis. TXA has been used for years in the management and prevention of hemorrhage in the surgical setting, including cardiac, orthopedic, and trauma surgery.2,3 SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1199673252 ER -