TY - CHAP M1 - Book, Section TI - Cytotoxics and Antimetabolites A1 - Wellstein, Anton A1 - Sausville, Edward A. A2 - Brunton, Laurence L. A2 - Knollmann, Björn C. PY - 2023 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition AB - AbbreviationsABVD:adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazineADA: adenosine deaminaseALL: acute lymphoblastic leukemiaAML: acute myeloid leukemia; acute myelocytic leukemiaAPL: acute promyelocytic leukemiaAra-C: cytarabine, cytosine arabinosideAra-U: ara-uridineL-ASP:L-asparaginaseATO: arsenic trioxideATRA: all-trans retinoic acidAUC: area under the curveBCNU: carmustine [1,3-bis-(2-chloroethyl)-1-nitrosourea]BCRP: breast cancer resistance proteinCCNU: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (lomustine)CDK: cyclin-dependent kinaseCHOP:cyclophosphamide, doxorubicin (H), vincristine (O), and prednisoneCLCr: creatinine clearanceCLL: chronic lymphocytic leukemiaCML: chronic myelocytic leukemia; chronic myelogenous leukemiaCSF: cerebrospinal fluidCTCL: cutaneous T-cell lymphomadCK: deoxycytidine kinasedFdC: 2′,2′-difluorodeoxycytidine, gemcitabine5′-dFdU: 5′-deoxyfluorodeoxyuridineDHFR: dihydrofolate reductaseDPD: dihydropyrimidine dehydrogenaseFdUMP: fluorodeoxyuridine monophosphateFOLFIRINOX: FOLFOX plus irinotecanFOLFOX:folinic acid, 5FU and oxaliplatin5FU: 5-fluorouracilFUdR: fluorodeoxyuridine or floxuridine or 5-FUdRGART: glycinamide ribonucleotide transformylaseG-CSF: granulocyte colony-stimulating factorHbF: hemoglobin (fetal)HDM-L: high-dose MTX with leucovorin rescueHGPRT: hypoxanthine guanine phosphoribosyl transferaseHMG: high-mobility groupHRD: homologous recombination DNA repairHU: hydroxyureaIMP: inosine monophosphateMESNA: 2-mercaptoethanesulfonate-Na+MGMT:O6-alkyl, methyl guanine methyltransferaseMMR: mismatch repairMOPP: nitrogen mustard, oncovin (vincristine), procarbazine, and prednisone6MP: 6-mercaptopurineMRP: multidrug resistance-associated proteinMTIC: methyl-triazeno-imidazole-carboxamideMTX: methotrexateNab-paclitaxel: albumin-bound nanoparticle solution of paclitaxelNER: nucleotide excision repairPG: polyglutamatePgp: P-glycoproteinPML: promyelocytic leukemiaPRPP: 5-phosphoribosyl-1-pyrophosphateRAR: retinoic acid receptorRNR: ribonucleoside diphosphate reductaseROS: reactive oxygen speciesTEM: triethylenemelamineTEPA: triethylenephosphoramide6TG: 6-thioguanineThiotepa: triethylenethiophosphoramideTPMT: thiopurine methyltransferaseTS: thymidylate synthaseTTP: thymidine triphosphateVOD: veno-occlusive disease SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1193242010 ER -