TY - CHAP M1 - Book, Section TI - Acid–Base Disorders A1 - Zagelbaum, Nicole K. A1 - Minhas, Osmaan A1 - Mir, Sajid A. A1 - Obligado, Sergio A2 - Go, Ronaldo Collo PY - 2019 T2 - Critical Care Examination and Board Review AB - The human body needs to regulate free hydrogen ions (H+) within a narrow window in order to maintain proper protein structure and function. In the process of metabolizing carbohydrates, proteins, and fats, 15,000 mmol of volatile acid, carbon dioxide (CO2), is generated and another 50 to 100 mEq of nonvolatile acid is also produced.1 Despite this, free hydrogen ion concentration is maintained at level of 40 nmol/L (10−6 mmol/L).2 When describing hydrogen concentration of physiologic solutions, we refer to the pH of the solution rather than the actual concentration. The pH of a solution is defined by the following equation: SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1160185629 ER -