TY - CHAP M1 - Book, Section TI - Aminoglycosides A1 - MacDougall, Conan A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. PY - 2017 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - ORIGINSAminoglycosides are natural products or semisynthetic derivatives of compounds produced by a variety of soil actinomycetes. Streptomycin was first isolated from a strain of Streptomyces griseus. Gentamicin and netilmicin are derived from species of the actinomycete Micromonospora. The difference in spelling (-micin) compared with the other aminoglycoside antibiotics (-mycin) reflects this difference in origin. Tobramycin is one of several components of an aminoglycoside complex known as “nebramycin” that is produced by Streptomyces tenebrarius. It is most similar in antimicrobial activity and toxicity to gentamicin. In contrast to the other aminoglycosides, amikacin, a derivative of kanamycin, and netilmicin, a derivative of sisomicin, are semisynthetic products. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/08 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1162544728 ER -